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学术报告:Green and highly efficient synthesis and asymmetric organocatalysis
日期:2017/12/21 10:03:10  发布:化学生物与材料工程学院  浏览: 736

时间:2017年12月26日(星期二)  下午14:00

地点:逸夫楼B-139


主讲人:张炜教授

                                        

        张炜,美国麻省州立大学化学正教授及绿色化学中心主任,第九批国家“千人计划”入选者。南京大学学士,美国匹兹堡大学化学博士及博士后。历任美国杜邦公司研究员,美国氟相技术公司开发部主任。现任美国麻省州立大学化学正教授及绿色化学中心主任;南京理工大学,上海应用技术大学,浙江师范大学客座教授。第九批国家“千人计划”入选者,也先后入选江苏省高层次创新创业人才,浙江省“千人计划”。是国际氟相化学,自由基化学,组合化学和绿色化学领域的领军人物。已发表论文186篇(包括专著2本,SCI引用5,000多次,获4项美国专利(新农药及氟相技术)并有3项专利申请(抗癌及抗HIV药)。在19个国家作过170多次学术讲座和会议报告,是7个国际期刊编辑(委),多个国际绿色化学及医药学会会员,组织过10个国际学术会议。是两任美国总统绿色化学挑战奖评审委员会委员,2015年在意大利荣获国际氟相技术奖(International Fluorous Technology Award)。

 

Abstract: This presentation highlights our recent effort on the development of fluorous chemistry based pot-economic synthesis and asymmetric catalysis to maximize reaction and separation efficiency in the synthesis of diverse heterocyclic scaffolds with substitution, skeleton, and stereochemistry variations. Recyclable organocatalyst-promoted cascade reactions have been introduced for asymmetric fluorination, Michael addition, Mannich reaction, Robinson annulation and other transformations to construct drug-like molecules with multiple stereocenters. Screening of our compounds for druggable targets such bromodomains, kinases, RORt, and HIV-1 will be mentioned.

                                            

Representative Publications:

Green Techniques for Organic Synthesis and Medicinal Chemistry, 2nd Ed, Zhang, W.; Cue, B. W. Eds., Wiley, Chichester, 2017, in press.

Zhang, X.; Dhawan, G.; Muthengi, A.; Liu, S.; Wang, W.; Legris, M; Zhang, W. “One-pot and Catalyst-free Synthesis of Pyrroloquinolinediones and Quinolinedicarboxylates” Green Chem. 2017, 19, 3851–3855.

 Huang, X.; Liu, M.; Jasinski, J. P.; Peng, B.; Zhang, W. “Recyclable Organocatalysts for the One-pot Asymmetric Synthesis of 2-Fluorocyclohexanols Bearing Six Contiguous Stereocenters” Adv. Synth. Catal. 2017, 359, 1919−1926.

Target Engagement by a Series of BI2536 Analogues with Miniaturized BET-BRET” ChemMedChem 2016, 11, 2575-2581.

McKeown, M.; Shaw, D.; Fu, H.; Liu, S.; Xu, X.; Marineau, J.; Huang, Y.; Zhang, X.; Buckley, D.; Lin, C.; Kadam, A.; Zhang, Z.; Blacklow, S.; Qi, J.; Zhang, W.; Bradner, J. “Biased multicomponent reactions to develop novel bromodomain inhibitors” J. Med. Chem. 2014, 57, 9019-9027.

Zhang, W. “Fluorous Linker-Facilitated Chemical Synthesis” Chem. Rev. 2009, 109, 749-795.

 

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                                                                          化学生物与材料工程学院

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